Thrombin-activable Factor X Re-establishes an Intrinsic Amplification in Tenase-deficient Plasmas
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چکیده
منابع مشابه
Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas.
Classical hemophilia results from a defect of the intrinsic tenase complex, the main factor X (FX) activator. Binding of factor VIIa to tissue factor triggers coagulation, but little amplification of thrombin production occurs. Handling of hemophilia by injection of the deficient or missing (thus foreign) factor often causes immunological complications. Several strategies have been designed to ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m507846200